CALL FOR PAPERS Cellular Mechanisms of Tissue Fibrosis Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization
نویسندگان
چکیده
Hiroe Toba, Lisandra E. de Castro Brás, Catalin F. Baicu, Michael R. Zile, Merry L. Lindsey, and Amy D. Bradshaw Mississippi Center for Heart Research and San Antonio Cardiovascular Proteomics Center, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan; Department of Physiology, East Carolina University, Greenville, North Carolina; Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina; Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina, and G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi
منابع مشابه
Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.
To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related cardiac inflammation, we studied six groups of mice: young (3-5 mo old), middle-aged (10-12 mo old), and old (18-29 mo old) C57BL/6 wild-type (WT) and SPARC-null (Null) mice (n = 7-10/group). Cardiac function and structure were determined by echocardiography. The left ventricle was used for cytokine g...
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